Cancer Gene Therapy (MDR)
IL-2 Gene Transfer Chemosensitizes MDR Cancer Cells
Published in Gene Therapy Weekly, November 3rd, 1997
MDR is one of the major obstacles to effective cancer treatment and often is associated with the expression of a variety of MDR-associated genes, including mdr1, LRP and MRP. mdr1 and MRP code for energy-dependent efflux pumps while the LRP gene encodes a vault protein. All of these gene products contribute to the establishment of the MDR phenotype in resistant tumor cells.
In previous research, researchers U. Stein and colleagues from the Max-Delbruck-Center for...
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Source: Gene Therapy Weekly (1997-11-03)
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