"Adenovirus-Mediated Transduction of Ribozymes Abrogates HER-2/neu and Pleiotrophin Expression and Inhibits Tumor Cell Proliferation."

According to the authors' abstract of an article published in Gene Therapy, "The combination of specific gene targeting technologies with efficient gene delivery systems could provide the to evaluate the concept of anticancer strategies ed to block expression of potentially rate-limiting tumor promoting factors. Here, we constructed adenoviruses expressing hammerhead-ribozymes targeted to two of these factors, the tyrosine kinase receptor HER-2/neu or the growth factor pleiotrophin (PTN). Adenovirus-mediated transduction of either HER-2/neu- or PTN-targeted ribozymes depleted the respective RNAs and inhibited protein expression significantly in three different human cancer cell lines. ...

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