Leukemia

Abnormal Gene Transcription And Acute Leukemia Linked

Published in Gene Therapy Weekly, November 17th, 1997

Research over the past 10 years has shown that acute leukemia is, in fact, a genetic disorder. It arises when genes essential to correct blood cell function are not expressed at the appropriate times.

In many cases, the failure of gene expression can be traced to an altered protein known as a transcription factor.

A. Thomas Look, M.D., in an article published in the November 6, 1997 issue of Science, estimates that as many as one-half of all childhood leukemia cases result from abnormal transcription factors. Dr. Look, chairman of Experimental Oncology at St. Jude Children's Research Hospital in Memphis, Tennessee noted that fused transcription...

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Source: Gene Therapy Weekly (1997-11-17)

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