Cancer Gene Therapy

Gene Transfer of mrp Protects Cells from Chemotherapeutic Agents

Published in Gene Therapy Weekly, November 17th, 1997

Retrovirus-mediated transduction of the multidrug resistance-associated protein (MRP) cDNA protects cells from chemotherapeutic agents via a different mechanism of action than gene transfer of the multidrug resistance (mdr-1) gene.

One of the major limitations of chemotherapy is its toxic effects on hematologic tissues. Several studies have transduced hematopoietic cells successfully with the mdr-1 gene to protect the cells from the toxic effects of chemotherapy. Not only can this protect these cells from standard doses of chemotherapeutics, but it could also allow for dosage escalation in situations where the cancer cells have lost their sensitivity to...

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Source: Gene Therapy Weekly (1997-11-17)

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