Published in Gene Therapy Weekly, November 24th, 1997
Thomas J. Wickham and colleagues from the University of Pittsburgh, Pennsylvania, and GenVec, Inc., Maryland, collaborated on the development of Ad vectors with increased delivery efficiency to targeted tissues ("Increased In Vitro and In Vivo Gene Transfer by Adenovirus Vectors Containing Chimeric Fiber Proteins," Journal of Virology, November 1997;71(11):8221-29).
"Alteration of the natural tropism of adenovirus will permit gene transfer into specific cell types and thereby greatly broaden the scope of target...
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