Vector Development

Alterations to Adenovirus Increase Gene Transfer Ability

Published in Gene Therapy Weekly, November 24th, 1997

Modifications to the adenovirus (Ad) fiber coat protein produces Ad vectors with increased in vitro and in vivo gene transfer abilities.

Thomas J. Wickham and colleagues from the University of Pittsburgh, Pennsylvania, and GenVec, Inc., Maryland, collaborated on the development of Ad vectors with increased delivery efficiency to targeted tissues ("Increased In Vitro and In Vivo Gene Transfer by Adenovirus Vectors Containing Chimeric Fiber Proteins," Journal of Virology, November 1997;71(11):8221-29).

"Alteration of the natural tropism of adenovirus will permit gene transfer into specific cell types and thereby greatly broaden the scope of target...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Gene Therapy Weekly

Source: Gene Therapy Weekly (1997-11-24)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry