"Inhibition Growth of Multidrug Resistant KBV200 Cells by MDR1 Antisense RNA."

According to the authors' abstract of an article published in Biochemical and Biophysical Research Communications, "Acquisition of resistance to multiple drugs of tumor cell caused by overexpression of the MDR1 gene is one of major obstacles in cancer chemotherapy. We have attempted to reverse the multidrug resistance (MDR) phenotype by treating vincristine (VCR) and adriamycin (ADM) resistant KBV200 cells with MDR1 antisense RNA. Retroviral vector expressing the antisense RNA was transfected into KBV200. In the transfected cells, a stable expression of antisense RNA and a reduction of cellular MDR1 mRNA could be detected by RT-PCR, and a reduction of MDR1 specific P-glycoprotein (P-gp)...

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