Xenotransplantation
"Genetic Engineering as an Approach to Xenotransplantation."
Published in Gene Therapy Weekly, December 15th, 1997
According to the author's abstract of an article published in World Journal of Surgery, "A discordant organ xenograft, such as a heart or kidney transplanted from pig to human, is rejected within 1 to 2 hours by a process called hyperacute rejection (HAR) caused in large or full measure by preexisting host xenoreactive natural antibodies (XNAs) and complement. HAR can be averted by blocking either complement or XNAs; but the xenograft is then rejected at 3 to 4 days by a process called delayed xenograft rejection (DXR), which can occur without the presence of T cells. DXR involves type II endothelial cell (EC) activation (the phase of activation that includes up-regulation of...
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Source: Gene Therapy Weekly (1997-12-15)
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