Cancer Gene Therapy

Cloned Gene Produces Telomerase Activity in Normal Human Cells

Published in Gene Therapy Weekly, December 15th, 1997

Geron Corp., Menlo Park, California, announced in the journal Nature Genetics that it has, for the first time, produced telomerase activity in normal, mortal human cells using the recently cloned gene for the human telomerase catalytic protein.

Telomerase is a rarely-expressed enzyme believed to play a key role in the regulation of cell lifespan, functioning as part of a molecular clock of cell aging. Its absence imparts mortality to some cells and its presence imparts replicative immortality to others.

"Reconstituting telomerase activity, especially in normal human cells, is a major milestone in telomerase biology that has widespread implications...

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Source: Gene Therapy Weekly (1997-12-15)

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