Cancer Gene Therapy

100 Percent Sorting Achieved After Retroviral-Mediated Tagging

Published in Gene Therapy Weekly, December 22nd, 1997

Use of a truncated CD5 gene as a cell surface marker allows researchers to reach 100 percent cell sorting efficiencies in retrovirally transduced bone marrow (BM) cells.

A major obstacle for many gene therapy protocols is making sure that every cell slotted for transduction is actually transduced with the therapeutic gene before being introduced into the patient. Failure to do this can result in decreased therapeutic efficacy and/or the introduction of therapy resistant cells into the patient.

Aiming for 100 percent selection of transduced cells, B. Garcia-Hernandez and colleagues from the Instituto de Microbiologia Bioquimica and the...

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Source: Gene Therapy Weekly (1997-12-22)

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