Cancer Immunotherapy
"Combination Gene Therapy for Hepatocellular Carcinoma Using Herpes Simplex Virus Thymidine Kinase and Interleukin-2 Gene."
Published in Gene Therapy Weekly, February 9th, 1998
According to an abstract submitted by the authors to the 48th Annual Meeting of the American Association for the Study of Liver Diseases, held November 7-11, 1997 in Chicago, Illinois, "Hepatocellular carcinoma (HCC) has been known to arise multi-centrically in the chronically diseased liver such as cirrhosis and chronic hepatitis. It is often complicated with intra- and extra-hepatic metastasis, resulting in difficulty of curing HCC. In this study, we analyze the effect of cancer vaccine induced by the gene therapy using herpes simplex virus thymidine kinase (HSV-tk) and interleukin-2 (IL-2) gene on the distant tumor growth. MH134 mouse hepatoma cells were infected with recombinant...
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Source: Gene Therapy Weekly (1998-02-09)
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