Published in Gene Therapy Weekly, February 9th, 1998
TBE occurs over a wide expanse of Europe and the former Soviet Union. The two most common TBE in Europe are caused by the flaviviruses Central European encephalitis (CEE) virus and Russian spring summer encephalitis (RSSE) virus. In 1976, a formalin-inactivated, chicken embryo-derived vaccine was introduced in Europe and since its introduction, the number of cases of TBE have declined.
Despite the initial success of this vaccine, it suffers from several disadvantages common to inactivated virus vaccines, including 1) the large-scale production and...
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