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HIV Gene Therapy

CD34+ Cells From HIV Patients Respond To Genetic Manipulation

Published in Gene Therapy Weekly, February 16th, 1998

University of California researchers demonstrated that gene targeting of hematopoietic progenitor cells of HIV positive patients may be a viable therapeutic regimen.

Recently, U. Junker et al., (Blood 1997;8:4299-4306; and others) demonstrated that granulocyte colony-stimulating factor (G-CSF) could be used to mobilize CD34+ cells in HIV positive individuals without severe side effects or increased viral burden.

Based on this understanding, A. Gervaix and colleagues from the University of California at San Diego, suggested that G-CSF could be used to mobilize sufficient numbers of CD34+ progenitor cells from HIV positive...

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