Vector Development
"An Efficient Selection System for Packaging Herpes Simplex Virus Amplicons."
Published in Gene Therapy Weekly, March 9th, 1998
According to the authors' abstract of an article published in Journal of General Virology, "Due to their simplicity and flexibility of genomic construction, herpes simplex virus (HSV) amplicon-based vectors are attractive vehicles for gene delivery. However, a significant problem faced in the generation of amplicon stocks is the low amplicon to helper virus (A/H) ratio. In order to improve the proportion of amplicons generated, a selection system for amplicon production was developed in which the HSV thymidine kinase (TK) gene is inserted into an amplicon plasmid and an HSV mutant with both TK and glycoprotein H (gH) genes deleted is used as a helper virus. Using a protocol in which...
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Source: Gene Therapy Weekly (1998-03-09)
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