Published in Gene Therapy Weekly, March 9th, 1998
Mesothelin is a 40-kDa glycosylphosphatidylinositol-linked glycoprotein that is present on the surface of several types of human cancers including ovarian carcinoma and rare mesotheliomas. In normal tissues, it is present only on mesothelial cells. Mesothelin is membrane-bound and is not detected in the blood of cancer patients nor shed in the medium from cultured cells.
Partha S. Chowdhury and colleagues from the U.S. National Cancer Institute, Maryland, suggested that the presence of mesothelin on the...
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