"Ligand-Targeted Receptor-Mediated Vectors for Gene Delivery."

According to the author's abstract of an article published in Expert Opinion on Therapeutic Patents, "Gene therapy promises to cure human genetic diseases. One of the main obstacles to fulfilling this promise is in the ability to target a gene to a significant population of cells and express it at adequate levels for a long enough period of time. Viral methods for gene delivery have been studied for a number of years and are effective vectors for gene transfer. The great majority of gene therapy clinical trials currently in progress use retroviruses or adenoviruses. However, there are concerns for their clinical use because of possible risks of mutagenesis, immunogenic side-effects and...

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