Genetic Engineering (Vaccines)
Chimeric Measles Virus Vaccine Protects Against Other Pathogens
Published in Gene Therapy Weekly, March 16th, 1998
Membrane glycoproteins drive the assembly and budding of enveloped RNA viruses. These proteins are the key players in determining the virus' host range and tissue tropism. This host range and tissue tropism can be altered by changing the viral envelop protein(s); this is called pseudotyping.
Pius Spielhofer and a team of researchers from the University of Zurich, Switzerland, created chimeric measles viruses by pseudotyping with vesicular stomatitis virus (VSV) ("Chimeric Measles Viruses with a Foreign Envelope," Journal of...
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Source: Gene Therapy Weekly (1998-03-16)
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