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Cancer Gene Therapy

 bax Overexpression Induces Apoptosis in Breast Cancer Cells

Published in Gene Therapy Weekly, March 30th, 1998

Adenovirus-mediated overexpression of the proapoptotic gene, Bax, induced apoptosis in human breast cancer cells.

Apoptosis is controlled in part by members of the Bcl-2 gene family; the proapoptotic genes (Bax, Bak, Bcl-XS ) and the antiapoptotic genes (Bcl-2, Bcl-XL ). Alterations in the balance of these genes can result in the suppression or induction of apoptosis.

S. Pearson, representing colleagues from the University of Texas M.D. Anderson Cancer Center, presented data at the 1st World Congress of Surgical Oncology, held March 26-29, 1998, in San...

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