Cancer Immunotherapy
"In Vivo Recruitment of Dendritic Cells Followed by Immunization With Mutant p53 Peptide Primes for Cytotoxic T Cell Response."
Published in Gene Therapy Weekly, April 6th, 1998
According to an abstract submitted by the authors to the Cancer Symposium, jointly sponsored by Society of Surgical Oncology and the World Federation of Surgical Oncology Societies, held March 26-29, 1998, in San Diego, California, "Introduction: Dendritic cells (DCs) arc the most potent professional antigen presenting cells (APCs). T cell immunity is important in tumor rejection and DCs are capable of stimulating naive T cells. A potential target for immune response to soft tissue sarcoma is mutated p53 which is over-expressed in >50% of human sarcomas. We investigated the effect of in vivo gene transfer of plasmid DNA encoding granulocyte/macrophage colony stimulating...
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Source: Gene Therapy Weekly (1998-04-06)
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