Endocrinology

Obesity, Puberty and Growth Linked to Same Gene

Published in Gene Therapy Weekly, April 6th, 1998

Obesity, puberty and growth may be controlled by the same gene, French scientists said.

Although leptin is known as the so-called "fat gene," Karine Clement, Laboratoire de Nutrition et Service de Medecine et Nutrition in Paris, France, and colleagues have found evidence that a defect in the gene also caused abnormal sexual and reproductive development in humans.

"It's the same gene. Probably the leptin pathway (chain reaction) is important in controlling many things in the brain, including growth, puberty and metabolism through thyroid function," Philippe Froguel, one of the researchers, said in an interview.

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Source: Gene Therapy Weekly (1998-04-06)

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