"Prevention of Renovascular and Cardiac Pathophysiological Changes in Hypertension by Angiotensin II Type 1 Receptor Antisense Gene Therapy."

According to the authors' abstract of an article published in Proceedings of the National Academy of Sciences of the United States of America, "Hypertension produces pathophysiological changes that are often responsible for the mortality associated with the disease. However, it is unclear whether normalizing blood pressure (BP) with conventional therapy is effective in reversing the pathophysiological damage. The duration and initiation of treatment, site of administration, and agent used all appear to influence the reversal of the pathophysiological alterations associated with hypertension. We have previously established that retrovirally mediated delivery of angiotensin II type 1...

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