"Different Effects of Gene Transfer of Cytokine Inhibitors into Human Synovial Fibroblasts Using the SCID Mouse Model for Rheumatoid Arthritis."

According to an abstract submitted by the authors to the Keystone Symposia on Molecular and Cellular Biology, Pathogenesis of Rheumatoid Arthritis: Implications for Future Therapy, held January 23-29, 1998, in Tamarron, Colorado, "Rheumatoid arthritis (RA) is characterized by a progressive destruction of joints. Using a retroviral vector for gene delivery into synovial fibroblasts, the effects of overexpression of different cytokine inhibitors on invasivity of RA synovial fibroblasts into cartilage, and on perichondrocytic cartilage degradation, was examined in the SCID mouse model for RA. Gene transfer of interleukin-1 receptor antagonist (IL-1Ra) followed by IL-1Ra overexpression...

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