"In Vivo Gene Therapy of Arthritis with Exogenous Cell Cycle Regulator."

According to an abstract submitted by the authors to the Keystone Symposia on Molecular and Cellular Biology, Pathogenesis of Rheumatoid Arthritis: Implications for Future Therapy, held January 23-29, 1998, in Tamarron, Colorado, "Synovitis of rheumatoid arthritis involves immune abnormality and massive proliferation of synovial cells. Current therapeutic approaches are largely aimed at immunomodulation to correct the underlining immune abnormalities, but not at direct suppression of the synovial cell hyperplasia. In the present study, a cyclin-dependent kinase (CDK) inhibitor, p16 gene was introduced into the inflamed knee joints of rat with adjuvant arthritis, a rat model of...

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