Gene Delivery (Vascular Tissue)
"Constitutive Expression of phVEGF(165) After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia."
Published in Gene Therapy Weekly, May 11th, 1998
According to the authors' abstract of an article published in Circulation, "Background: Preclinical studies have indicated that angiogenic growth factors can stimulate the development of collateral arteries, a concept called 'therapeutic angiogenesis.' The objectives of this Phase I clinical trial were (1) to document the safety and feasibility of intramuscular gene transfer by use of naked plasmid DNA encoding an endothelial cell mitogen and (2) to analyze potential therapeutic benefits in patients with critical limb ischemia. Methods and Results: Gene transfer was performed in 10 limbs of 9 patients with non-healing ischemic ulcers (n=7/10) and/or rest pain (n=10/10)...
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Source: Gene Therapy Weekly (1998-05-11)
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