Cancer Vaccines
"Immunization of Mice with the Synthetic Nonasaccharide KH-1 Results in Antibodies Against Adenocarcinoma Cells."
Published in Gene Therapy Weekly, June 8th, 1998
According to an abstract submitted by the authors to the 89th Annual Meeting of the American Association for Cancer Research, held March 28 - April 1, 1998, in New Orleans, Louisiana, "KH-1 antigen (Fuc(alpha)a12Gal(beta)14(Fuc(alpha)13)GlcNAc(beta)13gal(beta)14(Fuc(alpha)13) GlcNAc(beta)13Gal(beta)14Glc(beta)11Cer) is an adenocarcinoma associated carbohydrate antigen, defined by murine monoclonal antibodies AH6 and KM-1, containing a terminal Ley and an internal Lex epitope. Based on its known distribution, it is a potential target for active immunization with vaccines. KH-1 nonasaccharide was synthesized (Deshpande, P.P., and Danishefsky, S.J. Nature 387:164-166,...
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Source: Gene Therapy Weekly (1998-06-08)
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