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DNA Vaccines (Malaria)

Boosting with Vaccinia Increases Efficacy of Malaria DNA Vaccine

Published in Gene Therapy Weekly, July 27th, 1998

Primary inoculation with DNA, followed by boosting with a recombinant vaccinia virus, increased the immunogenicity and protective efficacy of a malaria vaccine.

To enhance the efficacy of DNA malaria vaccines, Martha Sedegah and colleagues from the Naval Medical Research Institute, Maryland, the University of Maryland School of Medicine, Vical, Inc., California, and Virogenetics Corporation, New York, evaluated the protective effect of immunizing with various combinations of DNA, recombinant vaccinia virus, and a synthetic peptide ("Boosting with Recombinant Vaccinia Increases Immunogenicity and Protective Efficacy of Malaria DNA Vaccine," Proceedings of the National...

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