Hematopoiesis

Delayed Targeting of Nonresponsive CD Cells Enhances Transduced Gene Expression

Published in Gene Therapy Weekly, August 10th, 1998

The prolonged stimulation of primitive hematopoietic progenitor cells is necessary to achieve retroviral-mediated gene transfer into cells that are capable of sustaining long-term hematopoiesis in vitro, study findings indicate.

Primitive hematopoietic progenitor cells (HPCs) are potential targets for the treatment of numerous hematopoietic diseases, by using retroviral-mediated gene transfer (RMGT). To achieve high efficiency of gene transfer into primitive HPCs, a delicate balance between cellular activation and proliferation and maintenance of hematopoietic potential must be established.

P. Veena and colleagues demonstrated that a subpopulation...

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Source: Gene Therapy Weekly (1998-08-10)

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