Cancer Gene Therapy
"New pH-Sensitive Liposomes for Non-Cationic Lipofection of Cancer Cell Lines."
Published in Gene Therapy Weekly, September 7th, 1998
According to an abstract submitted by the authors to the 6th Symposium on Gene Therapy: Towards Gene Therapeutics, held May 4-6, 1998, at the Max Delbruck Center for Molecular Medicine, Berlin-Buch, Germany, "This work is aimed to avoid certain complications in employing cationic liposomes which are not suitable for targeted gene delivery. In opposite to the cationic ones liposomes formed of neutral lipids without the use of cationic lipids can be employed as systems for targeted gene delivery. Liposomes were formed from neutral phospholipids (PC, cardiolipin, sphingomyelin) and pH-sensitive agents (glycyrrhizic acid (GA) or atocopheroylsuccinate (TS) (10:1, w\w) using reverse phase...
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Source: Gene Therapy Weekly (1998-09-07)
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