Long-Term Transfection (Keratinocytes)

Optimized Retroviral Infection Facilitates Long-Term Gene Expression

Published in Gene Therapy Weekly, September 21st, 1998

Optimization of gene transfer methods and grafting conditions facilitates long-term gene expression in transplanted grafts of keratinocytes.

Numerous retrovirally-mediated protocols have been used to attempt long-term gene expression in human epidermal keratinocytes in vivo, and for the most part, have had limited success. Most failures are attributed to a failure to target epidermal stem cells, suboptimal grafting conditions, or inactivation of the retroviral vector.

Because keratinocyte grafts are highly attractive recipient cells for gene therapy, L. Levy and a team of researchers from France and the United Kingdom attempted to overcome these...

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Source: Gene Therapy Weekly (1998-09-21)

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