Gene Transfer

Scientists Succeed in Inserting Gene in Human Cells Via Artificial Chromosome

Published in Gene Therapy Weekly, September 21st, 1998

Using a promising new technique, University of North Carolina at Chapel Hill scientists have for the first time successfully inserted large circular plasmids into human cells and showed the genes functioned as if they belonged there. After more than a year, the genes continued to operate normally.

The work is important, researchers say, because it may offer a more effective method of transferring healthy genes into humans with various illnesses such as hemophilia, cystic fibrosis, and sickle cell anemia, and improve treatment.

"We have been able to do this with a piece of DNA five to 20 times the usual size scientists work with," said Dr. Jean...

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Source: Gene Therapy Weekly (1998-09-21)

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