Cancer Gene Therapy

Angiogenesis-Dependent Tumor Growth Can Be Suppressed In a Murine Model

Published in Gene Therapy Weekly, October 5th, 1998

The delivery of a secreted inhibitor of tumor angiogenesis via an adenovirus vector is another, potentially synergistic, gene therapy approach in the fight against cancer.

Most cancer gene therapy approaches are based on destruction of cancer cells rather than the prevention of tumor formation. H. Li and H. Lu and a team of colleagues from several institutions angled their gene therapy research towards the delivery of an angiogenesis inhibitor via an adenoviral vector ("Adenovirus-Mediated Delivery of a uPA/uPAR antagonist suppresses Angiogenesis-Dependent Tumor Growth and Dissemination in Mice," Gene Therapy, August 1998;5(8):1105-13).

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Source: Gene Therapy Weekly (1998-10-05)

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