AIDS Gene Therapy

HIV Disease-Slowing Mutation Discovered

Published in Gene Therapy Weekly, October 5th, 1998

A common genetic mutation significantly delays the progression of HIV disease, scientists at the U.S. National Institute of Allergy and Infectious Diseases (NIAID) have found.

Philip M. Murphy, MD, and David H. McDermott, MD, of NIAID's Laboratory of Host Defenses, led a research team that screened blood samples from HIV infected individuals for mutations in the gene for CCR5, a key HIV co-receptor. The CCR5 gene encodes a protein on human immune cells that helps HIV enter and infect those cells. Recent studies have shown that individuals who produce mutant forms of CCR5 protein are more likely to resist HIV infection or have slower HIV disease progression than...

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Source: Gene Therapy Weekly (1998-10-05)

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