Gene Therapy (Leishmaniasis)

Interferon-Gamma Gene Transfer Elicits Therapeutic Effect In Vivo

Published in Gene Therapy Weekly, October 19th, 1998

Interferon-gamma (IFNgamma) gene transfer elicited a therapeutic response against experimental visceral leishmaniasis both in vitro and in vivo.

IFNgamma, in both its natural endogenous form and when administered as an exogenous protein, has been shown to induce control over visceral Leishmania donovani in experimentally infected BALB/c mice.

To further characterize the therapeutic role of IFNgamma in host defense against intracellular L. donovani, Alice P. Taylor and Henry W. Murray of Cornell University Medical College, tested the efficacy of IFNgamma delivered by gene transfer in a murine in vitro and in vivo model ("Therapeutic...

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Source: Gene Therapy Weekly (1998-10-19)

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