"p53: Prospects for Cancer Gene Therapy."

According to the authors' abstract of an article published in Cytokines Cellular & Molecular Therapy, "Initially described as an oncogene, at the end of the 1980s, the wild-type p53 gene ( TP53) was later shown to be capable of suppressing the proliferation of transformed cells. In the following years, an increasing number of studies demonstrated that intact p53 function is essential for the maintenance of the non-tumorigenic phenotype of cells. Indeed, functional inactivation of the p53 protein is one of the most common alterations observed in human cancers. More recently, it has been shown that inactivation of the TP53 tumor suppressor gene may lead to...

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