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Melanoma (Etiology)

Scientists Find Clue to Skin Cancer Development

Published in Gene Therapy Weekly, November 9th, 1998

Meenhard Herlyn, D.V.M., and his research team from the Wistar Institute, Philadelphia, Pennsylvania, have been studying the evolution of melanoma, estimated to strike 40,300 and kill 17,400 Americans in 1998.

Herlyn's most recent studies focus on the "switch" that turns benign lesions into malignancies. Herlyn said, "This change determines the outcome of disease. By identifying the genes that turn the switch on, we can design new therapies to keep it turned off."

Thus far, two genes, Alphav and Beta3, which are found in the vitronectin receptor (a cell surface glycoprotein that promotes the spread of cells and often is found at sites of skin...

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