Antisense Technology
"Synergistic Cytotoxicity of bcl-2 Antisense Oligodeoxynucleotides and Etoposide, Doxorubicin and Cisplatin on Small-Cell Lung Cancer Cell Lines."
Published in Gene Therapy Weekly, November 30th, 1998
According to the authors' abstract of an article published in British Journal of Cancer, "Expression of Bcl-2 is life-sustaining for small-cell lung cancer cells and associated with drug resistance. In the present study, the interactions between the bcl-2 antisense oligodeoxynucleotide 2009 and the chemotherapeutic agents etoposide, doxorubicin, and cisplatin were investigated on small-cell lung cancer cell lines to search for synergistic combinations. The cell lines NCI-H69, SW2, and NCI-H82 express high, intermediate-high, and low basal levels of Bcl-2, respectively, which are inversely correlated with the sensitivities of the cell lines to treatment with oligodeoxynucleotide 2009 and...
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Source: Gene Therapy Weekly (1998-11-30)
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