Published in Gene Therapy Weekly, November 30th, 1998
Effective anti-cancer vaccines need to deliver antigen-encoding DNA specifically to antigen-presenting cells (APCs), especially dendritic cells (DCs), at inductive sites of immune responses in order to signal the immune system to the presence of cancerous cells.
Paola Paglia and a team of researchers from Italy and Germany tested the ability of an attenuated bacterial carrier strain to act as an oral cancer vaccine ("Gene Transfer in Dendritic Cells, Induced by Oral DNA Vaccination with Salmonella...
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