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Cancer Immunotherapy

Synthetic Lipopeptide Induces Tumoricidal Activity

Published in Gene Therapy Weekly, November 30th, 1998

A liposome containing a new synthetic bacterial lipopeptide is a potent activator of macrophage tumoricidal properties.

I. Eue and colleagues from the University of Texas MD Anderson Cancer Center studied activation to the tumoricidal state of murine peritoneal macrophages by liposomes containing a new synthetic analogue, JBT3002, of a lipoprotein from the outer wall of a gram negative bacterium ("Induction of Nitric Oxide Production and Tumoricidal Properties in Murine Macrophages by a New Synthetic Lipopeptide JBT3002 Encapsulated in Liposomes," Journal of Immunotherapy, September 1998;21(5):340-351).

"The liposomes containing JBT3002 or CGP31362...

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