Gene Transfer

HIV Vectors Mediate High Efficiency Gene Transfer

Published in Gene Therapy Weekly, November 30th, 1998

HIV vectors mediated high efficiency gene transfer into fresh, resting human hematopoietic stem cells.

Recent research has shown the possibilities of gene transducing quiescent, G₀ /G₁ hematopoietic stem cells (HSC). As such, lentivirus vectors such as HIV-1 that encode proteins that permit transport of the viral genome into the nucleus of nondividing cells have come under close scrutiny as potential gene therapy vectors.

N. Uchida and colleagues from Stemcells, Inc., compared the transduction efficiencies of two different vector types ("HIV, But Not Murine Leukemia Virus, Vectors Mediate High Efficiency Gene Transfer into...

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Source: Gene Therapy Weekly (1998-11-30)

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