Gene Transfer

Cycle Modulation Increases Transduction Efficiencies

Published in Gene Therapy Weekly, December 7th, 1998

Modulation of cell cycles in primitive human hematopoietic cells increases transduction by a retroviral vector.

The stable transduction of hematopoietic stem cells (HSC) is required for the success of several different types of gene therapy. The safest and most effective retroviral vectors for the stable transfer of genetic DNA into target cells is the Moloney murine leukemia virus (MoMLV) vector. However, the transduction of HSC by MoMLV is thwarted by the need for these cells to be in mitosis and most stem cells are in a quiescent state.

Mo A. Dao and a team of researchers from several institutions hypothesized that a reduction in the levels of...

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Source: Gene Therapy Weekly (1998-12-07)

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