Diabetes Gene Therapy

Insulin Gene Modified Fibroblasts Affect Blood Glucose Levels

Published in Gene Therapy Weekly, December 7th, 1998

Fibroblasts that had been modified to express the human insulin gene changed the blood glucose level of diabetic rats after injection.

H. Wang and colleagues from the Chinese Academy of Medical Sciences, China, studied the effect of human insulin gene modified fibroblasts on the blood glucose levels of diabetic rats ("Construction of Human Insulin Gene Expression Recombinant and Its Effect on Blood Glucose of Diabetic Rats," Chinese Medical Journal, October 1998;111(10):899-902).

"An expression vector containing human insulin gene was constructed by recombinant DNA technique and introduced into fibroblast Ltk(-) cells by lipofectin-mediated DNA...

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Source: Gene Therapy Weekly (1998-12-07)

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