Published in Gene Therapy Weekly, December 7th, 1998
D.V. Schaffer and colleagues from the Salk Institute, California, suggested that molecular conjugates, or polyplexes, can be promising synthetic vectors for targeted, in vivo gene delivery if their efficiency can be improved ("Optimization of Cell Surface Binding Enhances Efficiency and Specificity of Molecular Conjugate Gene Delivery," Journal of Biological Chemistry, October 23, 1998;273(43):28004-28009).
As such, they suggested that by gaining mechanistic information on conjugate gene delivery, that one could potentially create significant improvements in...
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