Cancer Gene Therapy
IGF-I Antisense cDNA Induces Apoptosis in HCC Model
Published in Gene Therapy Weekly, December 14th, 1998
S. Ellouk-Achard and colleagues from the Laboratoire de Genetique Moleculaire, France, developed a gene therapy strategy based on the observation that IGF-I is necessary for the acquisition and maintenance of the transformed phenotype in hepatocarcinoma ("Induction of Apoptosis in Rat Hepatocarcinoma Cells by Expression of IGF-I antisense cDNA," J. Hepatol., November 1998;29(5):807-18).
"This strategy consists of transfecting the rat hepatoma cell line with an episomal vector expressing the antisense IGF-I cDNA under the control of the metallothionein I...
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Source: Gene Therapy Weekly (1998-12-14)
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