Published in Gene Therapy Weekly, December 14th, 1998
IL-17 is a novel cytokine that is secreted primarily by CD4+ T cells. Research has demonstrated that IL-17 supports the growth of hemopoietic progenitors in vitro, however, its in vivo effects are not well known.
P. Schwarzenberger and colleagues from the Louisiana State University Medical Center in New Orleans, Louisiana found that adenovirus-mediated gene transfer of the murine IL-17 cDNA targeted to the liver (5x109) plaque-forming units (PFU) intravenous resulted in a transiently transgenic phenotype, with dramatic...
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