Chemotherapy

CD Gene Expressed in Transduced Hematopoietic Cells

Published in Gene Therapy Weekly, December 21st, 1998

A drug-resistant gene inserted into hematopoietic cells may be useful in cancer therapy.

The chemotherapeutic effectiveness of cytosine nucleoside analogues used in cancer therapy is limited by their dose-dependent myelosuppression.

One approach to overcome this problem would be to insert the drug-resistant gene cytidine deaminase (CD), into normal hematopoietic cells. CD catalyzes the deamination and pharmacological inactivation of cytosine nucleoside analogues, such as cytosine arabinoside (Ara-C), noted N. Eliopoulos and colleagues ("Retroviral Transfer and Long-Term Expression of Human Cytidine Deaminase cDNA in Hematopoietic Cells following...

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Source: Gene Therapy Weekly (1998-12-21)

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