Published in Gene Therapy Weekly, December 21st, 1998
One approach to overcome this problem would be to insert the drug-resistant gene cytidine deaminase (CD), into normal hematopoietic cells. CD catalyzes the deamination and pharmacological inactivation of cytosine nucleoside analogues, such as cytosine arabinoside (Ara-C), noted N. Eliopoulos and colleagues ("Retroviral Transfer and Long-Term Expression of Human Cytidine Deaminase cDNA in Hematopoietic Cells following...
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