Published in Gene Therapy Weekly, February 8th, 1999
L. Benimetskaya and colleagues from Columbia University, New York, explored the use of cationic porphyrins as novel delivery vehicles for ODNs ("Cationic Porphyrins: Novel Delivery Vehicles for Antisense Oligodeoxynucleotides," Nucleic Acids Research, December 1, 1998;26(23):5310-5317).
"Cationic porphyrins form stable complexes with oligo-deoxynucleotides," wrote Benimetskaya et al. "To evaluate delivery, we used a 20mer phosphorothioate oligomer (Isis 3521) targeted to the 3'-untranslated region of the PKC-alpha mRNA, and complexed it...
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