Published in Gene Therapy Weekly, February 15th, 1999
As therapeutic agents, oligonucleotides have been extensively studied for their potential. Research has shown that phosphorothioate oligonucleotides are particularly useful for several reasons. They are stabile against nucleases, they can be internalized by many cell types, and they easily hybridize with target mRNA.
With the aid of iontophoresis, these compounds can be delivered across the skin. Experiments have shown that during transdermal delivery, the first viable cells exposed to the oligonucleotides are the...
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