Cytokine Gene Therapy

Intratumoral AdV-Mediated TNF-(alpha) Induces Tumor Regression

Published in Gene Therapy Weekly, February 15th, 1999

Intratumoral inoculation of an adenovirus (AdV) expressing the fusion protein RM4 and tumor necrosis factor (TNF)-(alpha) induces significant solid tumor regression.

TNF-(alpha) is an immunoregulatory cytokine that can enhance the cytotoxic activities of macrophages, neutrophils, and cytotoxic T cells. Unfortunately, therapeutic doses of systemic TNF-(alpha) can cause severe side effects in humans.

Studies have shown that the experimental transduction of tumors with various cytokine genes have caused the tumors to become more immunogenic, both in vitro and in vivo. Exploring a cytokine gene therapy approach to solid tumors, Philip Wright and...

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Source: Gene Therapy Weekly (1999-02-15)

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