Conference Coverage (Retrovirus)

Variable AIDS Progression Linked to MHC Gene Differences

Published in Gene Therapy Weekly, February 22nd, 1999

Small genetic differences may determine whether a person progresses rapidly or slowly to AIDS.

The suggestion comes from a study of a single family of macaque monkeys experimentally infected with SIVmac251, a pathogenic strain of simian immunodeficiency virus (SIV).

Two of the animals rapidly progressed to disease, both had identical major histocompatibility complex (MHC) class 1 alleles. They differed from two slow progressors only by a single MHC class 1 haplotype.

"Remarkably, this haplotype was shared by both slow progressors, and encoded two molecules used to present three different CTL [cytotoxic lymphocyte] epitopes...

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Source: Gene Therapy Weekly (1999-02-22)

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