Gene Transfer
"Interleukin-10 Gene Transfer Activates Interferon-gamma and the Interferon-gamma-Inducible Genes Gbp-1/Mag-1 and Mig-1 in Mammary Tumors."
Published in Gene Therapy Weekly, March 1st, 1999
According to the authors' abstract of an article published in International Journal of Cancer, "Expression of IL-IO as a transgene inhibits murine mammary tumor growth and metastasis. Using differential display methodology, we sought genes whose expression was modulated by IL-IO. We compared mRNA isolated from parental murine mammary 66.1 tumors, as well as tumors derived from neo(r)-transfected cells and 6 different IL-10-expressing cell lines. We identified 2 cDNA products that were upregulated in all 6 IL-10-expressing tumors in comparison to parental and 66-neo tumors. One cDNA corresponds to the murine guanylate-binding protein gene Gbp-1/Mog-1. The other cDNA corresponds to the...
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Source: Gene Therapy Weekly (1999-03-01)
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