Antisense Investigation

Downregulated Caveolin-1 Causes Cell Transformation

Published in Gene Therapy Weekly, March 1st, 1999

Targeted antisense-mediated downregulation of caveolin-1 helped demonstrate the pathogenesis of cell transformation related tumorigenesis.

F. Galbiati and colleagues from the Albert Einstein College of Medicine, New York, investigated the effect that downregulation of caveolin-1 has on tumorigenicity.

"Caveolin-1 is a principal component of caveolae membranes in vivo," wrote Galbiati et al. "Caveolin-1 mRNA and protein expression are lost or reduced during cell transformation by activated oncogenes."

Interestingly, noted the researchers, the human caveolin-1 gene is localized to a suspected tumor suppressor locus (7q31.1). ...

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Source: Gene Therapy Weekly (1999-03-01)

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